What is the difference between epoetin alfa and epoetin beta?

What is the difference between epoetin alfa and epoetin beta?

Epoetin beta was found to differ from epoetin alfa in containing: (a) a greater proportion of more basic isoforms, (b) a greater proportion of EPO binding to Erythrina cristagalli agglutinin (which binds N-glycans with nonsialylated outer Gal beta1-4GlcNAc moieties), and (c) isoforms with higher in-vivo:in-vitro …

Which is better erythropoietin alpha or beta?

Conclusion. In our assessment of hemodialysis patients, erythropoietin beta was found more effective than erythropoietin alpha.

Is epoetin alfa the same as Epogen?

Epogen (epoetin alfa) is an injectable medication used to treat low red blood cell count. It can have serious side effects, so it should only be used in certain types of people with anemia.

What type of injection is epoetin alfa?

Epoetin alfa injection products are used to treat anemia (a lower than normal number of red blood cells) in people with chronic kidney failure (condition in which the kidneys slowly and permanently stop working over a period of time).

What is the difference between erythropoietin and epoetin?

Epoetin injection is a man-made version of human erythropoietin (EPO). EPO is produced naturally in the body, mostly by the kidneys. It stimulates the bone marrow to produce red blood cells. If the body does not produce enough EPO, severe anemia can occur.

How do you inject epoetin with Alfa?

Adults—Dose is based on body weight and must be determined by your doctor. The starting dose is 100 units per kilogram (kg) injected into a vein or under the skin three times a week for 8 weeks. Your doctor may adjust the dose as needed. Children—Use and dose must be determined by your doctor.

What is the major difference between epoetin alfa and darbepoetin?

In the United States, epoetin alfa (EPO) is the predominant ESA used by large dialysis chains, whereas the more recently approved longer-acting ESA, darbepoetin alfa (DPO), is mainly used in independent and hospital-based dialysis units. In 2011, 94.1% of ESA-treated US hemodialysis patients used EPO and 5.9% used DPO.

What is the other name for epoetin alfa?

Epoetin alfa

Clinical data
Pronunciation /ɛˈpoʊ.ɪtɪn/
Trade names Epogen, Retacrit
Other names epoetin alfa-epbx
AHFS/Drugs.com Monograph

When do you inject epoetin with Alfa?

Adults—Dose is based on body weight and must be determined by your doctor. The starting dose is 300 units per kilogram (kg) injected under the skin for 10 days before the surgery, on the day of the surgery, and for 4 days after surgery. Children—Use and dose must be determined by your doctor.

Is Epogen the same as erythropoietin?

EPOGEN® is a prescription medicine for people on dialysis with anemia due to CKD that acts like a hormone called erythropoietin (ee-rith-row-PO-eh-tin). This hormone plays an important role in making red blood cells. EPOGEN® is used to treat anemia by helping the body create more red blood cells.

What is epoetin alfa used for?

Epoetin is used to treat severe anemia in patients on kidney dialysis or for those not on dialysis. Epoetin may also be used to prevent or treat anemia that is caused by surgery or medicines (eg, zidovudine) that are used for other conditions, such as HIV or cancer.

When do you use epoetin alfa?

Which injection is used to increase hemoglobin?

Is darbepoetin better than erythropoietin?

Similar trend of non-inferiority was observed for PP population (n=46). Safety profile of DA-α and EPO was similar. Conclusion: Our study results demonstrate that DA-α given at a reduced dose frequency is as effective and well tolerated as EPO for treating renal anemia in pre-dialysis patients with CKD.

What is darbepoetin alfa injection used for?

Darbepoetin may be used for patients on kidney dialysis or for those not on dialysis. Anemia can also occur in people who are receiving chemotherapy to treat cancer. Darbepoetin alfa is used to treat severe anemia in these patients.

What should I check before giving epoetin alfa?

It is very important that your doctor check the blood of you or your child on a regular basis while you are using this medicine. You may also need to monitor your blood pressure at home. If you notice any changes to your recommended blood pressure, call your doctor right away. .

Is epoetin alfa the same as erythropoietin?

Epoetin alfa is recombinant human erythropoietin, which is nearly identical to the endogenous hormone erythropoietin (EPO). Erythropoietin occurs in the peritubular cells of the kidney. Anemia and hypoxia are sensed by these cells and lead to the rapid secretion of EPO, which acts on erythroid marrow.

What is epoetin injection used for?

Which medicine is best to increase hemoglobin?

Drugs for Anemia

  • Carbonyl Iron. Carbonyl Iron is a dietary supplement, prescribed for iron deficiencies and iron deficiency anemia.
  • Cyanocobalamin (Vitamin B12)
  • Epoetin beta-methoxy polyethylene glycol.
  • Ferrous Ammonium Citrate.
  • Ferrous Fumarate.
  • Iron Sucrose.
  • Nandrolone.

Is erythropoietin and darbepoetin same?

Background: Darbepoetin alfa (DA-α) is a long-acting erythropoiesis-stimulating glycoprotein with a three-fold longer half-life than Erythropoietin alfa (EPO).

How do you administer epoetin?

– the upper outer area of the arm. – the front and outer sides of the thighs. – the abdomen, except for a 2 inch area around the navel. – the upper outer area of the buttocks. – the upper hip.

What conditions does epoetin alfa solution treat?


  • hives
  • itching
  • swelling of the face,throat,tongue,lips,or eyes
  • skin blisters or peeling skin
  • wheezing
  • difficulty breathing or swallowing
  • unusual tiredness
  • lack of energy
  • dizziness
  • What is the difference between epoetin alfa and darbepoetin alfa?

    No Clinical Difference Between Epoetin and Darbepoetin. There are no clinically significant differences in the safety and efficacy of epoetin alfa (Epogen, Procrit) and darbepoetin alfa (Aranesp), the two drugs most commonly used to treat anemia in cancer patients undergoing chemotherapy or radiation treatments, according to a new report by the

    What causes high erythropoietin levels?


  • alcohol abuse
  • smoking
  • high blood pressure (hypertension)