What does Karyopharm do?
Karyopharm Therapeutics is an innovation-driven pharmaceutical company focused on the discovery, development, and commercialization of medicines with the goal of improving the lives of patients with cancer and other major diseases.
Who manufactures Selinexor?
Selinexor was developed by Karyopharm Therapeutics, a pharmaceutical company focused on the development of drugs that target nuclear transport. It was approved in the United States in July 2019, on the basis of a single-arm Phase IIb clinical trial.
Where is karyopharm located?
Karyopharm Therapeutics Inc. Company Profile | Newton, MA | Competitors, Financials & Contacts – Dun & Bradstreet.
Is selinexor a chemotherapy?
Drugs used in chemotherapy, such as selinexor, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Is selinexor FDA approved?
Selinexor was approved with the FDA’s fast track and orphan drug designation, and, as a condition of accelerated approval, clinical trials are required to verify and describe selinexor’s benefit. Source: FDA press release, July 3, 2019.
Is selinexor an immunotherapy?
Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Selinexor is in a class of medications called selective inhibitors of nuclear export (SINE).
How is Xpovio given?
How is XPOVIO administered? In the Xd regimen, XPOVIO is given orally at a dose of 80 mg along with dexamethasone (20 mg orally) twice a week (both drugs on days 1 and 3 of a 28-day cycle) until disease progression.
How much does selinexor cost?
Although once-weekly SVd reduces the risk of disease progression as well as the cumulative exposure of patients to bortezomib and dexamethasone, selinexor is a costly drug-priced at nearly $22,000 per month-and is associated with significant toxicity.
How long do you live after being diagnosed with multiple myeloma?
Multiple myeloma is an uncommon cancer of the blood. The median length of survival after diagnosis with multiple myeloma is 62 months for Stage I, 44 months for Stage II, and 29 months for Stage III. Life expectancy depends on many factors, including the person’s age, health, kidney function, and more.
Can Myeloma be cured completely?
Treatment for multiple myeloma can often help control symptoms and improve quality of life. But myeloma usually can’t be cured, which means additional treatment is needed when the cancer comes back.
Is selinexor chemo?
Is Xpovio a chemo drug?
Xpovio contains the active drug selinexor. It’s a selective inhibitor of nuclear export (SINE), and it’s the first FDA-approved drug in this class. (A class of drugs is a group of medications that work in a similar way.) This drug is used to treat certain forms of cancer, but it’s not chemotherapy.
How effective is Xpovio?
This initial approval was based on data from a study that evaluated the effectiveness of the combination therapy in 83 patients with relapsed or refractory multiple myeloma. Overall 25.3% of patients responded to Xpovio and the median duration of response was 3.8 months.
What are the side effects of Selinexor?
Nausea, vomiting, diarrhea, loss of appetite, or weight loss may occur with selinexor, which can be severe and cause dehydration. Your doctor may give you medicine or other treatments for these. Check with your doctor right away if you notice that you are losing weight or have a decrease in appetite.
What is the newest treatment for multiple myeloma?
The latest approval is for the combination of daratumumab plus hyaluronidase-fijh (Darzalex Faspro) plus carfilzomib (Kyprolis) and the steroid dexamethasone for the treatment of adults with relapsed or refractory multiple myeloma who received one to three prior treatments.
What is the latest treatment for multiple myeloma?
What happens if you stop treatment for multiple myeloma?
But when treatment stops working, myeloma cells start growing again. It’s called a relapse. Relapse is common for people with multiple myeloma. In fact, this cancer is known as a “remitting and relapsing” disease.
What are the side effects of Xpovio?
Common side effects of XPOVIO include:
- low red blood cell count (anemia). Symptoms may include tiredness and shortness of breath.
- shortness of breath.
- increased blood sugar.
- changes in body salt and mineral levels in your blood.
- changes in kidney and liver function blood tests.