What drugs are somatostatin analogs?
What drugs are somatostatin analogs?
Somatostatin analogs are a synthetic form of somatostatin hormone and are used to reduce the production of various hormones in the body, particularly hormones produced by tumors. The U.S. Food and Drug Administration approved three drugs, namely, octreotide, Ianreotide, and pasireotide in this drug class.
Is octreotide a somatostatin analog?
The most common somatostatin analogue drugs used are octreotide (also known as Sandostatin) and lanreotide (also known as Somatuline Autogel).
Is Sandostatin and somatostatin the same?
Somatostatin is an orphan drug manufactured by Ferring Laboratories of Tarrytown, NY, under the trade name Reducin. Octreotide (Sandostatin) is a long-acting synthetic analogue of somatostatin. It has similar qualitative effects, but differs in potency and selectivity for target issues.
What hormone is octreotide an analog of?
Octreotide can also be used in the treatment of acromegaly, a disorder of excessive growth hormone (GH). Octreotide, being a somatostatin analog, inhibits the release of GH from the pituitary gland through a process normally involved in negative feedback.
What is the drug Sandostatin used for?
Sandostatin and Sandostatin LAR Depot are FDA-approved to treat severe diarrhea and flushing (warmth and redness in your skin) related to metastatic carcinoid tumors. A carcinoid tumor is a type of cancer that usually develops in your lungs or digestive system.
What is a octreotide somatostatin?
Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural hormone, somatostatin, which inhibits the secretion of growth hormone.
What class of medication is Sandostatin?
Sandostatin belongs to a class of drugs called Antidiarrheals; Somatostatin Analogs. It is not known if Sandostatin is safe and effective in children.
What is the difference between Sandostatin and Sandostatin LAR?
Sandostatin® is a short acting version and Sandostatin LAR® is a long acting version. Sandostatin® is given by subcutaneous injection (S.C. – the layer of tissue between the skin and the muscle). It may be necessary to take the shot several times a day.
What is the purpose of Sandostatin?
What is Sandostatin given for?
Sandostatin is given to control symptoms such as diarrhea or flushing in patients with tumors such as carcinoid, pancreatic islet cell tumors, gastrinoma, or vasoactive intestinal peptide-secreting tumors (VIPomas).
Is Sandostatin and octreotide the same thing?
Octreotide (also known as Sandostatin) is a man made (synthetic) version of the natural hormone somatostatin. You might have it as a treatment: for carcinoid syndrome. to control the growth of some advanced neuroendocrine tumours (NETs) when surgery is not possible.
What kind of drug is Sandostatin?
Sandostatin is a prescription medicine used to treat the symptoms of Acromegaly (production of too much growth hormone), Carcinoid Tumor, VIPoma. Sandostatin may be used alone or with other medications. Sandostatin belongs to a class of drugs called Antidiarrheals; Somatostatin Analogs.
What are somatostatin analogs used for?
Somatostatin analogs are used for treatment of tumors secreting vasoactive intestinal peptide, carcinoid tumors, glucagonomas and various pituitary adenomas.
What is the difference between octreotide and somatostatin?
Somatostatin is a 14 amino acid peptide that inhibits pancreatic exocrine and endocrine secretion. Its clinical application has been limited by its very short half life, necessitating continuous intravenous infusion. Octreotide is an 8 amino acid synthetic analogue of somatostatin that possesses sim …
What are some medical conditions associated with somatostatin?
Medical conditions associated with somatostatin and somatostatin analogs: Acromegaly. Carcinoid Syndrome. Carcinoid Tumor. Cushing’s Syndrome. Diabetes, Type 1. Diarrhea. Dumping Syndrome.
How to target somatostatin receptors in tumors?
The so-called targeting approach takes advantage of the presence of somatostatin receptors on different tumors. By coupling octreotide structural elements to so-called cage molecules complexing B or Y emitting isotopes, also the detection of somatostatin receptor containing tumors could be visualized and treated.