Which is HMG-CoA reductase inhibitor?
Which is HMG-CoA reductase inhibitor?
A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood. HMG-CoA reductase inhibitor drugs are called statins.
What is another name for HMG-CoA reductase inhibitor?
Hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, also known as “statins,” are used adjunctively to diet and exercise to treat hypercholesterolemia by lowering total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) concentrations while increasing high-density lipoprotein …
What is the function of HMG-CoA reductase?
Function. HMG-CoA Reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum …
How HMG-CoA reductase inhibitors work?
Also known as statins, HMG-CoA reductase inhibitors work by inhibiting the synthesis of cholesterol in the liver by the enzyme HMG-CoA reductase.
What are some important counseling points for statins?
Monitoring. Prior to starting treatment, the patient should have a blood test to obtain pre-treatment cholesterol levels, as well as to check liver function. They should then expect to have another blood test within three months of starting treatment and again at 12 months to monitor the effectiveness of the statin.
How do you remember ACE and pril?
The easy way to remember ACE inhibitors is their drug names usually end with the suffix “pril”. Examples include lisinopril, enalapril, captopril, quinapril, and benazepril. ACE Inhibitor List of Example Medications: ACE inhibitor drug names usually end in “pril”.
What is the MOA of ACE inhibitors?
ACE inhibitors prevent an enzyme in the body from producing angiotensin II, a substance that narrows blood vessels. This narrowing can cause high blood pressure and forces the heart to work harder. Angiotensin II also releases hormones that raise blood pressure.
What is the significance of HMG-CoA?
HMG-CoA is the precursor for cholesterol synthesis. HMG-CoA is formed by condensation of acetyl-CoA and acetoacetyl-CoA, catalyzed by HMG-CoA synthase. HMG-CoA reductase catalyzes the production of mevalonate from HMG-CoA, in which the HMG-CoA reductase reaction is the rate-limiting step for cholesterol synthesis.
What happens when you inhibit HMG-CoA reductase?
Inhibition of HMG-CoA reductase, a rate-limiting enzyme in hepatic cholesterol synthesis by statins, results in the reduction of intracellular cholesterol content that in turn induces an increase in SREBP-2-mediated hepatic LDL receptor synthesis (Sahebkar and Watts, 2013b) (Chapter 11).
What is the mechanism of HMG-CoA reductase?
HMG-CoA reductase catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of HMG-CoA to mevalonic acid (MVA in Figure 2). It is considered to be the rate-limiting enzyme of the cholesterol biosynthetic pathway.
What’s HMG-CoA?
What are the 7 statins?
Statins include atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor, Ezallor) and simvastatin (Zocor, FloLipid). Having too much cholesterol in your blood increases your risk of heart attacks and strokes.
Do ACE inhibitors decrease preload or afterload?
ACE inhibitors reduce afterload, preload, and systolic wall stress100 –109 such that cardiac output increases without an increase in heart rate. ACE inhibitors promote salt excretion by augmenting renal blood flow and by reducing the production of aldosterone and antidiuretic hormone.
What is the difference between ACE inhibitors and beta blockers?
In addition to their antihypertensive actions, beta-blockers are used to manage arrhythmias and treat angina pectoris and heart failure, while ACE inhibitors provide cardioprotection in patients with acute coronary syndromes and treat congestive heart failure.
Why are ACE inhibitors first line for heart failure?
ACE inhibitors are at least as beneficial as digitalis in patients with mild heart failure, and they may even be considered as first-line therapy. Promising results have also been obtained in patients with myocardial infarction, in whom long-term therapy with ACE inhibitors has prevented an increase in heart size.