Which organ gets affected in dengue?
Which organ gets affected in dengue?
The liver as a target of immune-mediated mechanisms in dengue fatal cases. The liver is considered as an important target for DENV infection and is the most common organ to be involved in the disease. Hepatic alterations are key characteristics found in DENV cases.
Does dengue affect liver and kidney?
Most patients with dengue fever recover following a self-limiting febrile illness, while a small proportion may progress to develop severe disease with complications such as acute liver failure, acute kidney injury, and multiorgan failure.
Is dengue effect on kidney?
Dengue and Kidney disease. Dengue infection has been associated with a variety of renal disorders. Acute renal failure, proteinuria, hematuria, and glomerulonephritis have been reported during or shortly after acute dengue infection.
How does dengue fever differ from cholera?
Cholera, a bacterial illness, can be acquired when sources of drinking water have been contaminated. Malaria is caused by a parasite, and a virus causes Dengue Fever. Both malaria and Dengue fever are carried by mosquitoes, which lay their larvae in still water.
Is liver affected in dengue?
DENV INFECTION AND LIVER The liver is the commonest organ to be involved in dengue. Hepatic manifestations are either a result of direct viral toxicity or dysregulated immunologic injury in response to the virus.
Which organ is affected in chikungunya?
In this model, at the early stage of the disease, the organs targeted for CHIKV replication were lymphoid tissues, liver, CNS, joints, and muscle, and the persistence of CHIKV could be found later in the lymphoid organs, liver, joints, and muscle, macrophages being the main reservoir for persistent CHIKV infection.
Can dengue cause acute liver failure?
Dengue-associated acute liver failure was most common among young adults (median age, 29 years). The median duration from onset of fever to development of acute liver failure was 7.5 days. Patients with the severe stage of dengue had a higher risk of developing acute liver failure (P < 0.001).
Does dengue affect liver?
This disease has been found to have profound effect on multiple organ systems, the commonest being the liver. Starting from asymptomatic elevated transaminase levels to acute liver failure (ALF), dengue has all the properties of a hepatic illness.
Does chikungunya affect kidney?
It is possible that a direct kidney damage can be caused by CHIKV (cytopathic effect of viral proteins on glomerular and tubular cells), associated with immune complex deposition on glomeruli, as has been described for other arbovirus infections such as dengue and Zika.
How does cholera affect the body?
A bacterium called Vibrio cholerae causes cholera infection. The deadly effects of the disease are the result of a toxin the bacteria produces in the small intestine. The toxin causes the body to secrete enormous amounts of water, leading to diarrhea and a rapid loss of fluids and salts (electrolytes).
How does dengue affect the body?
Severe dengue happens when your blood vessels become damaged and leaky. And the number of clot-forming cells (platelets) in your bloodstream drops. This can lead to shock, internal bleeding, organ failure and even death. Warning signs of severe dengue fever — which is a life-threatening emergency — can develop quickly.
How does dengue affect the organ system?
Why is liver affected in dengue fever?
Varying degrees of liver involvement are seen during acute dengue infection and are thought to result from hepatocyte apoptosis directly by the virus, hypoxic damage due to impaired liver perfusion resulting from fluid leakage, oxidative stress or immune mediated injury [6–8].
Does chikungunya affect liver?
Chikungunya virus has a wide tissue and cellular tropism and previous reports indicate that it infects the liver [76, 77].
What is the difference between dengue and chikungunya?
Whereas Dengue can cause bleeding in some cases, breathing problems, etc. In Chikungunya, rashes all across the face, palms, feet, limbs can be found whereas, in Dengue, rashes are limited to limbs and face. Complications such as chronic arthritis and rare neurological problems are possible in Chikungunya.
Why is liver affected in dengue?
Does liver swell in dengue?
“Dengue virus attacks the cells that cause inflammation in the liver. The Alanine Aminotransferase (ALT) and Amino Alanine Transferase (AST) enzymes increase in number in the blood during the time and may cause complications including damage to liver,“ infectious diseases and internal medicine expert Mahesh Lakhe said.
What causes hepatomegaly in dengue?
The spectrum of hepatic involvement in dengue varies from jaundice to elevation of liver enzymes. Hepatomegaly is a most important clinical sign. Elevation of liver enzymes can occur with or without hepatomegaly. Significant rise of liver enzymes helps in recognition of severe forms of dengue infection (DHF and DSS).
How does cholera affect the immune system?
It is believed that the immune response to cholera is initiated by antigen presentation in the Peyer’s patches of the gastrointestinal mucosa, followed by migration of the stimulated antigen-specific B cells to regional lymph nodes and differentiation of these cells into specific antibody-secreting cells (28).