What is the normal vancomycin trough level?
What is the normal vancomycin trough level?
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough levels is 5-15 mcg/mL. The reference range for vancomycin peak levels is 20-40 mcg/mL.
What does it mean when vancomycin trough is high?
Based on pooled adjusted OR, high vancomycin trough level is the variable that was identified as the independent factor associated with risk of nephrotoxicity in MRSA infections. MRSA-infected patients with trough levels ≥15 mg/L had greater odds of nephrotoxicity than those with trough levels <15 mg/L.
How do you evaluate vancomycin effectiveness?
Vancomycin efficacy in bacterial killing is associated with the area under the plasma concentration-time curve from 0 to 24 hours (AUC0-24) over minimum inhibitory concentration (MIC). 1, 6-10 Clinical efficacy is more likely to be achieved when vancomycin dosing achieves an AUC0–24/MIC ≥ 400.
When do you check vancomycin trough levels?
Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) – Trough levels should be obtained within 30 minutes before the next scheduled dose. – Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function.
What are peak and trough levels?
The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug. The peak level is the highest concentration of a drug in the patient’s bloodstream.
What is the maximum dose of vancomycin?
In non-obese adults with normal kidney function, they recommend a loading dose of 20-35mg/kg/day, with a maximum dose of 3000mg given in a single dose. For non-obese children and neonates, a loading dose is not recommended. If the adult patient is obese, loading doses of 20-25mg/kg using actual body weight, up to 3000mg may be considered.
What are the side effects of vancomycin capsules?
– Hives, skin rash – redness or other discoloration of the skin – scaling or welting of the skin
How to dose vancomycin?
Drug action. The glycopeptide antibiotic vancomycin has bactericidal activity against aerobic and anaerobic Gram-positive bacteria including multi-resistant staphylococci.
What is the renal dose of vancomycin?
The dosage of vancomycin per day in mg is about 15 times the glomerular filtration rate in mL/min: The initial dose should be no less than 15 mg/kg, even in patients with mild to moderate renal insufficiency. The table is not valid for functionally anephric patients.